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Is it true that Erythroderma Occurs Due to Drug Allergy? These are the Facts


“Allergies to certain drugs can cause erythroderma. This rare skin disease can cause severe rashes and scaling.”

Is it true that Erythroderma Occurs Due to Drug Allergy?  These are the Facts

Halodoc, Jakarta – Erythroderma aka exfoliative dermatitis is severe inflammation of the entire surface of the skin. This condition causes a red, scaly rash that is severe, and peels. As a result, this will cause problems with temperature regulation, loss of protein and fluids, and an increase in metabolic rate.

This disease can occur due to pre-existing skin conditions, and sometimes can also be due to cancer. In some cases, this disease can occur for no apparent reason or is idiopathic. However, is it true that drug allergies can be the cause? Come on, see the following review!

Erythroderma and Drug Allergy

Erythroderma is a rare skin disease. However, the disease can appear at any age and in people of all races. This disease most often affects children and young adults. However, certain forms of erythroderma are more common in middle-aged and elderly people.

According to a 2017 study in the journal majority, erythroderma can occur due to allergies or hypersensitivity to drugs and cutaneous T-cell lymphoma. Precisely due to complex interactions between cytokines and adhesion between cellular molecules that affect T cells in the skin.

Apart from being an allergic reaction to drugs, this rare skin disease can also occur due to several skin conditions, such as:

  • Dermatitis, especially atopic dermatitis.
  • Psoriasis, especially after withdrawal of systemic steroids or other medications.
  • Pityriasis rubra pilaris.
  • Diseases that cause blistering of the skin, including pemphigus and bullous pemphigoid.
  • Sezary’s syndrome (erythrodermic form of cutaneous T-cell lymphoma).
  • Some very rare congenital ichthyotic conditions.

Erythroderma can also be a symptom or sign of a systemic disease, such as:

  • Hematologic malignancies, such as lymphoma and leukemia.
  • Internal malignancies, such as carcinoma of the rectum, lung, fallopian tubes, colon, prostate (paraneoplastic erythroderma).
  • Graft-versus-host disease.
  • HIV infection.

Unfortunately, experts have not yet received an answer to why some skin diseases can become erythroderma. Its pathogenesis is complex, involving keratinocytes and lymphocytes, and their interactions with adhesion molecules and cytokines. The result is a dramatic increase in epidermal cell turnover.

What Are the Symptoms Like?

Each sufferer may experience different symptoms. However, the following are the most common signs and symptoms of erythroderma:

  • Extreme redness of the skin.
  • Crusted lesions.
  • Thick skin.
  • Itchy.
  • Swollen lymph nodes.
  • Fever.
  • Bad taste.
  • Secondary infection (viral or bacterial).
  • Loss of fluids and proteins through broken skin. This can lead to dehydration and protein deficiency.

Treatment Options

Erythroderma is potentially serious, even life-threatening, and sufferers may require hospitalization to monitor and restore fluid and electrolyte balance, circulatory status, and body temperature.

Special treatment for erythroderma will be determined by the doctor based on several important factors, such as:

  • Age, overall health condition, and medical history.
  • Extent of symptoms on the skin.
  • Tolerance to certain drugs, procedures, or therapies.
  • Hope for the course of the reaction.
  • Personal opinion or preference.

Here are some common actions that are part of the treatment of erythroderma:

  • Stop all unnecessary drug use.
  • Monitor fluid balance and body temperature.
  • Keep skin moisturised with moist emollient dressings and mild topical steroids.
  • Prescribe antibiotics for bacterial infections.
  • Antihistamines may be necessary to help relieve itching symptoms.

If a cause can be identified, then specific treatment should be initiated. Such as administering topical and systemic steroids for atopic dermatitis, drugs for psoriasis, or other drugs according to conditions.

That’s the discussion about a rare skin disease, erythroderma. If you or someone close to you experiences symptoms, immediately downloads Halodoc to make a hospital appointment with the doctor, yes.

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Reference:
majority. Accessed 2022. Erythroderma et causa Drug Allergy.
Derm Net. Retrieved 2022. What is Erythroderma?
Johns Hopkins Medicine. Accessed 2022. Generalized Exfoliative Dermatitis.



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Dr. Eka

A doctor, wife and mother of three. Spread the world with valid information.

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